Fitzwilliam College Music Society oversees all things musical at the College. It is one of the College's senior societies, bringing together undergraduates, postgraduates and Fellows; its Senior President is the Master, who chairs meetings and is actively involved in the Society's affairs.

Fitz has an opera company, Fitzwilliam Chamber Opera, presenting an annual show; a Musical Theatre Society, presenting an annual showcase and more; a fine Chapel Choir; excellent all-male and all-female a cappella groups in Fitz Barbershop and the Fitz Sirens; a long-term association with student big band Fitz Swing; a role in the Hill Colleges’ Orchestra-on-the-Hill, and a great many chamber groups and duos that come and go with their student membership. In addition, the Director of Music frequently puts together one-off ensembles for performances of particular works at College events, and student composers find ample possibilities for performance of their own works.