Guido Papa is a postdoctoral researcher at the MRC Laboratory of Molecular Biology (MRC LMB) whose current research focuses on understanding the molecular mechanisms driving replication of animal viruses like Influenza, HIV and SARS-CoV-2 and the role of the immune system in counteracting these processes.
He completed his PhD at the International Center for Genetic Engineering and Biotechnology (ICGEB) in Trieste (Italy), where he was involved in the development of systems to manipulate the viral genome of Rotavirus, a double-stranded RNA virus among the important human and animal pathogens. He generated several recombinant mutant rotaviruses to study processes directly involved in viral replication. During his PhD, he developed the first platform to edit genome of double-stranded RNA viruses using CRISPR-technology and uncovered a particularly discussed problem of rotavirus replication cycle.
As a molecular virologist, his research interests are mainly aligned to understanding host-virus interactions and its relationship with the immune system. During his postdoctoral experience in Cambridge he was directly involved in CoVID19 related research uncovering the role of Spike protein cleavage during SARS-CoV-2 infection. His research projects includes the study of HIV and how the virus is able to build a metastable capsid to ensure replication within the host cell, avoiding cellular innate immune sensing.