I am a mathematician and computational biologist working in genomics. Exciting new technologies have enabled investigation of how mutating a specific gene in a single cell affects the cell’s function in a variety of different conditions. I use statistics to improve the analysis of the data and to optimise the experimental setup, thereby contributing to improved understanding of how genes regulate other genes, of how this varies across individuals, and of how to best differentiate stem cells into more specialised cells.
I originally specialised in analysis and partial differential equations, but then did my PhD at the MRC Biostatistics Unit in Cambridge to specialise in probabilistic and statistical modelling for biology and medicine. I am now a Sir Henry Wellcome fellow at the European Bioinformatics Institute EMBL-EBI, the Wellcome Sanger Institute, and the Universities of Manchester and Kyoto. I supervise courses in probability and statistics.